In this coming-of-age novel, two Mexican-American teenagers, Aristotle and Dante, form an unlikely friendship during the summer of 1987. As they navigate their way through adolescence, they uncover the complexities of their identities, family dynamics, and the world around them. Through their shared experiences, they discover the power of love, self-acceptance, and the profound mysteries that the universe holds.

The book explores the profound and complex friendship between a physician and his medical student, both struggling with personal demons. The physician, dealing with the aftermath of a failed marriage, finds solace in his bond with the student, who is battling a severe addiction to drugs. Through their shared love of tennis, they navigate the challenges of their lives, offering each other support and understanding. The narrative delves into themes of addiction, recovery, and the healing power of friendship, set against the backdrop of the demanding world of medicine.

"Everything Begins and Ends at the Kentucky Club" is a collection of seven short stories, all of which are connected by the Kentucky Club, a bar in Ciudad Juárez, Mexico. The stories explore various themes such as love, loss, addiction, and identity, and feature a range of characters, from a young man coming to terms with his sexuality to an older man reflecting on his past relationships. The author uses the backdrop of the U.S.-Mexico border to highlight the complexities and struggles of the characters' lives.