Set in a small Ohio town in the 1890s, the novel revolves around the enigmatic character Brackett Omensetter, a man whose mere presence seems to affect those around him in profound and inexplicable ways. The story is narrated from the perspectives of three different characters: the town's eccentric and paranoid physician, a reverend tormented by his lack of faith, and a local man who becomes obsessed with Omensetter. The narrative explores themes of religion, morality, and the nature of luck and fate.

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