The novel explores the history of a fictional painting by Vermeer, as it passes through the hands of various owners. The narrative traces back from the present day to the time of the painting's creation, revealing the profound impact it has had on those who possessed it. The painting's subjects, a young girl in a blue dress, also becomes a symbol of beauty, loss, and the enduring power of art. The novel is a series of interconnected stories that together form a rich tapestry of human experience and the power of art to transform lives.

The 4858th greatest book of all time