In this science fiction epic, humanity faces an existential crisis when the moon suddenly explodes, triggering a catastrophic chain of environmental disasters on Earth. With only two years before the planet becomes uninhabitable, nations unite to launch a daring plan to preserve human life by sending a select group of survivors into orbit. The narrative spans thousands of years, chronicling the efforts of these initial survivors to maintain the human race in space, the political and social challenges they face, and the eventual attempt by their far-future descendants to return to a drastically changed Earth. The story is a sweeping examination of human resilience, ingenuity, and the enduring quest for survival against insurmountable odds.

Set in a future Thailand amidst a world ravaged by climate change and depleted resources, the story unfolds in a bustling city where biotech corporations vie for supremacy. The narrative centers around a genetically engineered "New Person," known as the Windup Girl, who is trapped in a life of servitude and exploitation. As the city teeters on the brink of political and environmental collapse, the fates of various characters—including a foreign energy investor, a disgraced geneticist, and a street-smart refugee—intertwine with that of the Windup Girl. Together, they navigate a treacherous landscape of corporate greed, oppressive government, and social upheaval, in a desperate search for survival and redemption in a world where every action has unforeseen consequences.

The novel explores the life of an autistic man who excels at pattern recognition while working for a pharmaceutical company. His orderly world is disrupted when he is offered an experimental treatment that could potentially "cure" his autism. The story delves into themes of identity, neurodiversity, and the ethical implications of altering the human brain. As he grapples with the decision of whether to undergo the treatment, the protagonist must confront questions about what it means to be normal and whether the changes would fundamentally alter who he is. The narrative challenges the reader to consider the value of individual differences and the societal pressures to conform.