"The Savage Detectives" is a novel that follows the lives of two Latin American poets, Arturo Belano and Ulises Lima, who are founders of a literary movement called "visceral realism." The book is divided into three parts and is narrated by multiple characters, providing different perspectives on the protagonists. The narrative spans over 20 years, following the poets' journey from Mexico City to Europe, Israel, and Africa, as they search for a mysterious poetess and navigate through the world of literature, sex, drugs, and the complexities of life.

The novel is a sprawling, ambitious work that spans continents and time periods, centering around an elusive, reclusive German author. It intertwines five different narratives: a group of European academics searching for the author, a professor in Mexico dealing with his own personal crises, a New York reporter sent to cover a boxing match in Mexico, an African-American journalist in Detroit, and the horrifying and unsolved murders of hundreds of women in a Mexican border town. The narratives are linked by themes of violence, mystery, and the search for meaning in a chaotic world.