The novel is a first-person narrative, a monologue by a young Jewish man, Alexander Portnoy, who is speaking to his psychoanalyst. He shares his struggles with his identity as a Jewish man in America, his sexual fantasies and frustrations, his complex relationship with his overbearing mother, and his experiences of guilt and shame. The book uses humor and frank language to explore themes of identity, sexuality, and the Jewish experience in America.

The book follows the lives of two Jewish cousins, one a skilled escape artist and the other a talented artist, before, during, and after World War II. They create a popular comic book superhero, which brings them fame and fortune. However, their success is complicated by personal struggles, including the escape artist's attempts to rescue his family from Nazi-occupied Prague and the artist's struggle with his sexuality. The narrative explores themes of escapism, identity, and the golden age of comic books.

The novel follows a young man living in Manhattan as he tries to navigate his way through the fast-paced and drug-fueled world of the New York City nightlife during the 1980s. He is struggling with his job at a prestigious magazine, his estranged wife who has left him for another man, and his growing addiction to cocaine. As he spirals further into self-destruction, he must confront his problems and make choices about the person he wants to be.

The novel is a comedic and poignant exploration of the intense and complex relationship between a young man and his overbearing mother. The story follows the protagonist as he grapples with the challenges of adolescence, the pressures of college admissions, and the pursuit of his individual identity, all under the watchful and often smothering affection of his mother. Her relentless involvement in every facet of his life leads to a series of humorous and uncomfortable situations, revealing the universal themes of familial love, the struggle for independence, and the often fraught dynamic between parents and their growing children.

The novel follows the story of a young aspiring playwright who moves to New York City with dreams of making it on Broadway. He becomes the protégé of an eccentric older gentleman, a self-styled "extra man" who escorts wealthy widows in the Upper East Side's high society. As the protagonist navigates his new life, he is drawn into a world of old-world manners, transgender escapades, and odd human connections, all while grappling with his own identity and aspirations. The narrative is a comedic and poignant exploration of loneliness, friendship, and the quest for personal authenticity in a city that often feels overwhelming and surreal.

"The Bear Comes Home" is a unique tale about a talking, saxophone-playing bear who navigates the human world while yearning for true freedom. The bear, who is also the protagonist, struggles with the complexities of human life, including love, art, and the search for self-identity. As he explores the jazz scene, he is caught between his bear nature and his human-like consciousness, leading to a profound exploration of what it means to be free and to be oneself.