This groundbreaking historical novel follows several generations of an African American family, beginning with Kunta Kinte, a man captured in Gambia in the 18th century and sold into slavery in the United States. Through Kinte and his descendants, the narrative explores the brutal realities of slavery and its aftermath, the struggle for freedom and civil rights, and the perseverance of a family through immense hardship. The story is based on the author's own family history, making it a significant work in the exploration of African American heritage and identity.

The book tells the story of Henrietta Lacks, a poor African American tobacco farmer whose cells, taken without her knowledge in 1951, became one of the most important tools in medicine, vital for developing the polio vaccine, cloning, gene mapping, and more. Henrietta's cells have been bought and sold by the billions, yet she remains virtually unknown, and her family can't afford health insurance. The book explores the collision between ethics, race, and medicine; of scientific discovery and faith healing; and of a daughter consumed with questions about the mother she never knew.

"Witness" is a gripping autobiography that chronicles the author's life as a Communist party member, his espionage activities for the Soviet Union, and his eventual renunciation of communism. The book also details his role as the key witness in the 1948 Alger Hiss trial, a high-profile case that had a major impact on American politics during the Cold War. The narrative explores themes of ideology, betrayal, and redemption, and provides a unique perspective on the ideological battles of the 20th century.