The novel follows the life of William Stoner, a farm boy turned academic, who becomes a professor of English literature at the University of Missouri. Despite his love for teaching and his passion for literature, Stoner's life is marked by a series of personal and professional disappointments, including a loveless marriage, an unsuccessful career, and a failed relationship with a fellow professor. Throughout his life, Stoner remains dedicated to his work, finding solace and purpose in his commitment to the life of the mind.

Set in the harsh poverty of the Ozarks, the story follows a determined, hard-bitten teenage girl who, in the face of her drug-dealing father's disappearance, takes on the responsibility of caring for her two younger siblings and mentally ill mother. When she learns their house will be taken away unless her father shows up for his court date, she embarks on a dangerous journey through the criminal underworld to find him, encountering violence and betrayal along the way.