"Love Medicine" is a novel that explores the lives of several generations of a Native American family living on a reservation in North Dakota. The narrative is presented through a series of interconnected stories, each told from the perspective of different family members, and spans over 60 years, from 1934 to 1999. The book explores themes of love, family, identity, and the struggle between tradition and modernity. It provides a deep and poignant look into the complexities of Native American life and culture, and the challenges faced by the community.

A teenage boy navigates the complexities of life after his mother is brutally attacked on their reservation in North Dakota. As the legal system fails to bring justice due to jurisdictional issues, the boy takes matters into his own hands. The novel explores themes of tribal law, justice, and the transition into adulthood, all set against the backdrop of Native American culture and history.

This book is a poignant memoir of a single man who adopts a three-year-old American Indian boy, only to discover several years later that his son suffers from fetal alcohol syndrome, a condition that was not well understood at the time. The narrative chronicles the man's journey to understand and cope with his son's condition, while also shedding light on the devastating effects of alcohol abuse on unborn children. The book also delves into the broader social issues surrounding Native American communities and the systemic problems that contribute to alcoholism among these populations.

In this emotionally charged novel, a man accidentally kills his neighbor's son while hunting and, in an act of ancient tribal tradition, offers his own son, LaRose, as compensation. The narrative explores the complexities of grief, justice, and cultural identity, as both families grapple with the loss of their sons and the impact of this decision. The story is set against the backdrop of the Ojibwe reservation in North Dakota, and the intertwining of the two families leads to unexpected relationships and the healing power of shared sorrow.