The book is a satirical novel set in post-independence Senegal, exploring themes of corruption, power, and tradition. It follows the story of a wealthy businessman who, after taking a third wife, finds himself afflicted with xala, a curse of impotence. His desperate attempts to cure his condition expose the hypocrisy and moral decay of the newly established elite, as he navigates the clash between modernity and traditional beliefs. The narrative serves as a critique of the neocolonialism that persists in African societies, highlighting the struggles between personal gain and societal progress.

The novel is a monologue by a young Pakistani man, Changez, who tells his life story to an American stranger in a café in Lahore. Changez recounts his journey from a scholarship student at Princeton to a high-flying job in a prestigious New York valuation firm and his subsequent disillusionment with the American Dream post 9/11. The story explores themes of identity, love, and the shifting global power dynamics, as Changez grapples with his feelings towards America, his native Pakistan, and his love interest, Erica. The narrative ends ambiguously, leaving the reader to interpret the true nature of Changez and his American listener's relationship.