A Prayer for Owen Meany by John Irving

The book is a tale of two childhood friends, one of whom believes he is God's instrument. The story is set in a New England town during the 1950s and 1960s and follows the lives of the two boys, one small and with a strange voice, who has visions of his own death and believes he is an instrument of God, and the other, the narrator, who struggles with faith. The novel explores themes of faith, fate, and the power of friendship against a backdrop of historical and political events, including the Vietnam War.

The 213th greatest book of all time