A small, fictional mill town in Maine called Empire Falls, though once booming in industry, is quickly deteriorating. Owned by the powerful Whiting family, the town can no longer sustain itself. Seen through the eyes of Miles Roby, the manager of the Empire Grill, which is also owned by Mrs. Whiting, his struggles with family, including his divorce and his teenage daughter, greatly mirror the condition of the town. His soon-to-be ex-wife Janine is going out with and preparing to marry the owner of a fitness center in town. As prospects for the town's future dwindle, the past is visited to explain Miles' history as well as those around him and the town itself. A subplot of the novel involves a school shooting carried out by a poor high school student, who is essentially orphaned after the death of his grandmother.