Middlesex by Jeffrey Eugenides

The book follows the life of Calliope Stephanides, a Greek-American hermaphrodite, who narrates her epic story starting from her grandparents' incestuous relationship in a small village in Asia Minor to her own self-discovery in 20th century America. The novel delves into themes of identity, gender, and the American dream, while also providing a detailed history of Detroit through the eyes of three generations of an immigrant family.

The 228th greatest book of all time