Middlesex by Jeffrey Eugenides
Middlesex is a novel by Jeffrey Eugenides. It was published in 2002 and won the Pulitzer Prize for Fiction in 2003. The narrator and protagonist, Calliope Stephanides (later called "Cal"), an intersexed person of Greek descent, has 5-alpha-reductase deficiency. The bulk of the novel is devoted to telling his coming-of-age story growing up in Detroit, Michigan in the late 20th century. This story, however, is intertwined with elements of a family saga, meditations on the era's zeitgeist and bits of contemporary history.