Set in the Venezuelan llano, the book tells the story of an ongoing struggle between two powerful landowners. One is Doña Bárbara, a ruthless and cunning woman who has used her cunning and seductive prowess to amass a large amount of land. The other is Santos Luzardo, an educated city-dweller who returns to the plains to reclaim his family's property. The novel explores themes of civilization versus barbarism, the struggle for land, and the magical realism of the South American landscape.

"Memorias de Mamá Blanca" is a nostalgic and lyrical novel that takes the form of a memoir, recounting the idyllic childhood and family life of a group of sisters growing up on a Venezuelan cacao plantation at the turn of the 20th century. Through the eyes of the protagonist, the narrative delves into the customs, traditions, and social norms of the Venezuelan upper class during that era, while also exploring themes of innocence, the passage of time, and the loss of the pastoral world. The story is imbued with a sense of melancholy as it reflects on the inevitable changes brought about by modernity and the impact these changes have on personal and cultural identity.