"Dinner at the Homesick Restaurant" is a novel about the life of the Tull family, which is marked by abandonment and discord, but also love and resilience. The story is told from the perspective of each family member, providing a unique viewpoint on the family's dynamics and history. The matriarch, Pearl, struggles to raise her three children, Cody, Ezra, and Jenny, after their father abandons them. Each child deals with the abandonment and their dysfunctional family in different ways, shaping their adult lives. The novel explores themes of family, love, abandonment, and the idea of home.

The novel follows the life of a travel writer, who, after the death of his son and subsequent separation from his wife, embarks on a journey of self-discovery. He meets an eccentric dog trainer who is the complete opposite of his introverted and orderly self. Through their relationship, he learns to embrace the unpredictability of life and move beyond his grief. The story is a poignant exploration of love, loss, and the unexpected turns life can take.

In "Searching for Caleb," a quirky, upper-class family is brought to life, with a focus on the Peck family's black sheep, Duncan. Duncan, who rejects the family's traditions and expectations, embarks on a quest to find his missing uncle Caleb, who disappeared decades ago without a trace. Alongside him is his cousin, Justine, who also feels out of place within their family. The novel explores themes of identity, family bonds, and the need for personal freedom.

The novel centers around Barnaby Gaitlin, a 30-year-old man who is still trying to shake off the bad reputation he earned in his youth. He works for Rent-a-Back, a service that helps elderly people with odd jobs, and he finds fulfillment in helping them. However, his family and the society still see him as a failure. He meets Sophia, a wealthy woman who doesn't fit into his world, and their relationship causes him to reevaluate his life and the choices he's made.

The novel delves into the complex dynamics of the Whitshank family, spanning across four generations, living in Baltimore, Maryland. The narrative weaves through time, unraveling the family's secrets, rivalries, and bonds as it focuses on Abby and Red, the aging parents, and their children who grapple with their own identities and relationships. The story explores themes of legacy, memory, and the nuanced fabric of familial love, all symbolized by the titular spool of blue thread, which holds sentimental value and represents the threads of stories that connect the family members to each other and to their shared past.