"Dinner at the Homesick Restaurant" is a novel about the life of the Tull family, which is marked by abandonment and discord, but also love and resilience. The story is told from the perspective of each family member, providing a unique viewpoint on the family's dynamics and history. The matriarch, Pearl, struggles to raise her three children, Cody, Ezra, and Jenny, after their father abandons them. Each child deals with the abandonment and their dysfunctional family in different ways, shaping their adult lives. The novel explores themes of family, love, abandonment, and the idea of home.

This novel revolves around a middle-aged couple, Ira and Maggie Moran, and their journey to a funeral. The story delves into their relationship dynamics, their regrets, and their hopes for the future. The narrative explores the complexities of marriage, the disappointments of parenthood, and the general trials and tribulations of life. The couple's interactions with other characters they meet along the way further illuminate their struggles and their enduring love for each other.

The novel follows the life of a travel writer, who, after the death of his son and subsequent separation from his wife, embarks on a journey of self-discovery. He meets an eccentric dog trainer who is the complete opposite of his introverted and orderly self. Through their relationship, he learns to embrace the unpredictability of life and move beyond his grief. The story is a poignant exploration of love, loss, and the unexpected turns life can take.

Set in early 20th century Baltimore, the novel follows the life of Miss Susie Slagle, a boarding house owner who rents out rooms to medical students. The narrative is full of colorful characters, including the students themselves, who bring their own unique stories and perspectives. The book provides a vivid depiction of the time period, exploring topics such as gender roles, class distinctions, and the challenges and triumphs of pursuing a medical career.

In "Searching for Caleb," a quirky, upper-class family is brought to life, with a focus on the Peck family's black sheep, Duncan. Duncan, who rejects the family's traditions and expectations, embarks on a quest to find his missing uncle Caleb, who disappeared decades ago without a trace. Alongside him is his cousin, Justine, who also feels out of place within their family. The novel explores themes of identity, family bonds, and the need for personal freedom.

The novel delves into the complex dynamics of the Whitshank family, spanning across four generations, living in Baltimore, Maryland. The narrative weaves through time, unraveling the family's secrets, rivalries, and bonds as it focuses on Abby and Red, the aging parents, and their children who grapple with their own identities and relationships. The story explores themes of legacy, memory, and the nuanced fabric of familial love, all symbolized by the titular spool of blue thread, which holds sentimental value and represents the threads of stories that connect the family members to each other and to their shared past.