Set in early 20th century Baltimore, the novel follows the life of Miss Susie Slagle, a boarding house owner who rents out rooms to medical students. The narrative is full of colorful characters, including the students themselves, who bring their own unique stories and perspectives. The book provides a vivid depiction of the time period, exploring topics such as gender roles, class distinctions, and the challenges and triumphs of pursuing a medical career.

The novel unfolds as a faux memoir, structured around a grandson's conversations with his dying grandfather, revealing a tapestry of secret histories and hidden truths. The narrative spans the grandfather's adventurous life, from his involvement in hunting Nazis during World War II to his personal and emotional battles on the home front. The story delves into themes of love, loss, and the impact of secrets through the lens of a family's complex dynamics, set against the backdrop of mid-20th-century America, blending historical events with the fantastical elements of space exploration and model rocketry.