The novel explores the spiritual isolation of misfits and outcasts in a small town of the U.S. South. Its protagonist is a deaf-mute who becomes the confidant for various troubled souls including a black physician, a bitter labor activist, a lonely young girl, and a struggling café owner. Each pours their heart out to him, but he remains unable to respond, reflecting the deep human need for connection and understanding.

This autobiographical account provides a vivid portrayal of Chinese-American life in the early 20th century through the eyes of a young girl growing up in San Francisco's Chinatown. The narrative follows her journey as she navigates the complexities of traditional Chinese family values and the American way of life, striving for educational and personal independence. The protagonist's struggle to reconcile her dual cultural heritage is compounded by her ambitions, as she seeks to assert her identity and pursue her dreams amidst the expectations of her family and community. Her story is one of resilience and self-discovery, offering insight into the immigrant experience and the challenges of cultural assimilation.

The novel is a reflective account of the life of Harry Pulham, a middle-aged, conventional Bostonian who is prompted to examine his past and the choices he has made during the process of writing a Harvard class reunion biography. As he delves into his memories, he confronts his youthful ambitions, his experiences in World War I, and his complex relationships, particularly with a vivacious woman who challenged the conservative values of his upbringing. Through this introspection, Harry grapples with the realization that he has conformed to societal expectations at the expense of his own happiness, leading to a poignant exploration of the conflict between individual desires and societal pressures in early 20th-century America.

This novel tells the story of the Timberlake family, focusing on two sisters, Stanley and Roy. Stanley is a selfish, manipulative woman who abandons her husband for her sister Roy's husband, causing a series of tragic events. Meanwhile, Roy, the more responsible and virtuous sister, must navigate the fallout of Stanley's actions. The book explores themes of family, morality, and the destructive power of selfishness, all set against the backdrop of the American South in the early 20th century.