The novel follows the life of Philip Carey, a club-footed orphan who struggles with his disability and his passionate and unrequited love for a destructive woman. His journey takes him from a strict religious upbringing in England to an adventurous life in Paris where he attempts to become an artist before finally settling into a career in medicine. The story is a powerful exploration of human desire, ambition, and the search for meaning in life.

This novel is a satirical critique of small-town life, following the story of a young, ambitious woman who moves from the city to a quiet, conservative town in the Midwest with her new husband. Despite her attempts to bring culture and progress to the town, she is met with resistance and ostracism from the closed-minded locals. The protagonist's struggle against traditional norms and her ultimate disillusionment highlight the stifling conformity and lack of intellectual stimulation in rural America.

This novel follows the story of Paul Pennyfeather, a young man studying at Oxford University who is unfairly expelled and forced to take a job as a teacher at a chaotic school in Wales. His life takes a turn when he meets a wealthy widow and gets sucked into the high society lifestyle, only to be betrayed and sent to prison. The narrative is a satirical critique of the British class system, education, and the moral corruption of the rich.

This novel tells the story of Dr. Wilbur Larch—saint and obstetrician, founder and director of the orphanage in the town of St. Cloud's, Maine, and a man of rare compassion and an addiction to ether. Dr. Larch loves all his orphans, especially Homer Wells, who is never adopted and becomes his invaluable apprentice. As Homer comes of age, he must leave the only home he's ever known to explore the world outside, a world filled with temptations and moral dilemmas, from the struggle over abortion to the question of what constitutes a family.

The novel follows the life of a bright and dedicated young man, Martin Arrowsmith, who dreams of making significant contributions to medical science. He faces a constant struggle between his ambition and the demands of his professional and personal life. His journey takes him from a small Midwestern town to the prestigious universities of the East Coast, and eventually to a deadly outbreak in the Caribbean. Throughout his journey, he grapples with the corruption, greed, and mediocrity that he finds pervading the medical field, all while trying to remain true to his scientific ideals.

This novel follows the poignant journey of two teenagers, both cancer patients, who meet in a support group and fall in love. Their shared experiences and unique outlook on life and death bring them closer together, and they embark on a trip to Amsterdam to meet a reclusive author they both admire. Through their journey, they explore the harsh realities of living with a terminal illness while also experiencing the beautiful and tragic aspects of first love.