The book follows the lives of two Jewish cousins, one a skilled escape artist and the other a talented artist, before, during, and after World War II. They create a popular comic book superhero, which brings them fame and fortune. However, their success is complicated by personal struggles, including the escape artist's attempts to rescue his family from Nazi-occupied Prague and the artist's struggle with his sexuality. The narrative explores themes of escapism, identity, and the golden age of comic books.

"A Visit from the Goon Squad" is an interconnected collection of stories about a group of characters whose lives intersect in the music industry. The narrative spans several decades, tracing the characters' journey from their youth to middle age. It explores themes of time, change, and the impact of technology on human relationships and the music industry. The novel is known for its experimental structure, including a chapter written as a PowerPoint presentation.

"The Last Gentleman" is a novel about a disoriented and confused man from the South who suffers from a "nervous condition" that causes him to forget who he is. When he meets a young man dying from a brain tumor, he decides to leave his home in New York and travel with the man and his family back to the South. Throughout his journey, he attempts to discover his own identity and grapples with existential questions about life, love, and death.

"Moon Palace" tells the story of Marco Stanley Fogg, an orphaned young man in New York City who embarks on a journey of self-discovery. As he ventures into the American West and delves into his family's past, he encounters a series of adventures and misadventures that challenge his understanding of identity, love, and the very nature of reality. The novel is a complex and symbolic exploration of American mythology, weaving together themes of solitude, survival, and the pursuit of the American Dream.

"Call Me Zebra" is a novel about a young woman, who is the last in a line of self-proclaimed "anarchists, atheists, and autodidacts," embarking on a grand intellectual journey. After her father's death, she retraces the path they took as refugees from Iran to New York, immersing herself in literature and philosophy to cope with her grief. The protagonist's eccentric perspective and her passionate, often humorous, engagement with the works of literature make for a unique exploration of exile, art, and identity.