The novel is a poignant tale set in the 1920s post-World War I era, focusing on a group of American and British expatriates living in Paris who travel to Pamplona, Spain for the annual Running of the Bulls. The story explores themes of disillusionment, identity, and the Lost Generation, with the protagonist, a war veteran, grappling with impotence caused by a war injury. The narrative is steeped in the disillusionment and existential crisis experienced by many in the aftermath of the war, and the reckless hedonism of the era is portrayed through the characters' aimless wanderings and excessive drinking.

This novel follows the life of Amory Blaine, an attractive and privileged young man who grows up in the early 20th century United States. It explores his experiences in prep school, at Princeton University, and in the real world after graduation, as well as his relationships with a series of young women. The protagonist's life is marked by his pursuit of wealth, status, and love, and his eventual disillusionment with the values of his society. The novel is a critique of the American Dream and a reflection on the lost generation of the 1920s.

The novel follows the life of Claude Wheeler, a young Nebraska native who is dissatisfied with his prosperous farming life. When the United States enters World War I, he sees it as an opportunity to find purpose and meaning, and enlists in the army. The book explores his experiences and struggles in the war, his longing for home, and his ultimate sacrifice, providing a poignant commentary on the impact of war on the individual and society.