The novel explores the life of an African-American man, Macon "Milkman" Dead III, from birth to adulthood. Set against the backdrop of racial tension in the mid-20th century United States, it delves into his journey of self-discovery and understanding his heritage. As Macon embarks on a literal and figurative journey south to reconnect with his roots, he encounters various characters that help him understand his family history and the power of community. The narrative is deeply rooted in African-American folklore and mythology, offering a profound commentary on identity, personal freedom, and the destructive power of racism.

The novel is a final look into the life of Harry "Rabbit" Angstrom, a former high-school basketball star, now in his mid-fifties, overweight and grappling with several health issues. Despite his success in business, his personal life is in shambles, with his wife addicted to alcohol and his son to drugs. Harry, struggling with his mortality, is trying to understand his past and make sense of his future, while dealing with the changing American society and the consequences of his own choices.

The novel follows the life of Daisy Goodwill Flett, a seemingly ordinary woman, from her birth in Canada in 1905 to her death. It explores her experiences as a mother, wife, and widow, as well as her work as a gardener and her later years as a columnist. The book is unique in that it is written in a variety of styles including letters, diary entries, and third-person narrative, and it explores themes of identity, love, and the often overlooked lives of women.

The novel centers around a woman named Amber who unexpectedly arrives and disrupts the lives of the Smart family while they are on summer holiday in Norfolk. Each family member - Eve, a writer, Michael, a university professor, and their children Astrid and Magnus - experience unique interactions with Amber, causing them to question their own realities. The mysterious woman's influence forces the family to confront their secrets, insecurities, and the false narratives they've created about themselves.

"October Light" is a story set in Vermont, revolving around an elderly brother and sister, James and Sally, who have lived together for decades but have a strained relationship due to their differing views. When James locks Sally in her room after an argument, she finds a novel within a novel, which becomes her only escape. The book explores themes of aging, isolation, and the clash of old and new values, all the while providing a commentary on the changing American society of the 1970s.