The novel presents the story of a wealthy Chinese woman who, upon reaching her 40th birthday, decides to change the course of her life. She arranges a concubine for her husband to take over her marital duties and embarks on a journey of self-discovery and liberation. Throughout the narrative, she explores the constraints of traditional roles and the possibilities of intellectual and spiritual freedom, forming a deep connection with a foreign missionary. This relationship challenges her beliefs and the societal norms of the time, leading her to question the very foundations of her existence and her place in the world.

The novel is a reflective account of the life of Harry Pulham, a middle-aged, conventional Bostonian who is prompted to examine his past and the choices he has made during the process of writing a Harvard class reunion biography. As he delves into his memories, he confronts his youthful ambitions, his experiences in World War I, and his complex relationships, particularly with a vivacious woman who challenged the conservative values of his upbringing. Through this introspection, Harry grapples with the realization that he has conformed to societal expectations at the expense of his own happiness, leading to a poignant exploration of the conflict between individual desires and societal pressures in early 20th-century America.

This novel tells the story of the Timberlake family, focusing on two sisters, Stanley and Roy. Stanley is a selfish, manipulative woman who abandons her husband for her sister Roy's husband, causing a series of tragic events. Meanwhile, Roy, the more responsible and virtuous sister, must navigate the fallout of Stanley's actions. The book explores themes of family, morality, and the destructive power of selfishness, all set against the backdrop of the American South in the early 20th century.