The novel is set in 1930s Edinburgh and follows the story of six girls under the tutelage of an unconventional teacher, Miss Jean Brodie. Miss Brodie, in her prime, takes it upon herself to educate the girls about life, love, politics, and art, often disregarding the traditional curriculum. The narrative explores the influence of Miss Brodie on the girls, the consequences of her nonconformist teachings, and the ultimate betrayal that leads to her downfall.

The novel is a historical tale set in 18th-century Scotland, revolving around Jeanie Deans, a young woman of strong moral character, who embarks on a daunting journey from Edinburgh to London to seek a royal pardon for her wrongfully accused sister, Effie, who faces execution. Along the way, Jeanie encounters various characters from different strata of society, confronting issues of justice, morality, and national identity. Her steadfast loyalty and unwavering principles highlight the cultural and social tensions of the time, as the narrative intertwines personal drama with broader historical events, including the Porteous Riots and the influence of the Scottish Reformation.