This book is a philosophical essay that explores the concept of absurdity, and how individuals should respond to life's inherent meaninglessness. It posits that life is essentially absurd due to the conflict between our desire for understanding and the chaotic, indifferent universe. The author argues that the only proper response to this absurdity is to live life to its fullest, embracing and rebelling against the absurdity, rather than resorting to suicide or turning to religion or philosophy for false comfort. The story of Sisyphus, condemned to eternally roll a boulder up a hill only for it to roll back down, is used as a metaphor for the human condition.

In this metatheatrical play, six characters come to life and demand that a theater director tell their tragic story, which was left incomplete by their author. As the director and his actors interact with these characters, the boundaries between fiction and reality blur, leading to a philosophical exploration of the nature of human identity, the reliability of art, and the unreliability of perception. The characters' story, involving a complex web of familial relationships, adultery, and suicide, further complicates the narrative, challenging the audience's understanding of truth and illusion.

The novel follows the adventures of an eccentric, violent, and mentally unstable protagonist who is released from an asylum by his psychiatrist. The pair embark on a chaotic journey across Europe and America, encountering a variety of strange and often dangerous situations. The narrative explores themes of insanity, violence, and the human condition, offering a dark and surreal critique of modern society.