"The Savage Detectives" is a novel that follows the lives of two Latin American poets, Arturo Belano and Ulises Lima, who are founders of a literary movement called "visceral realism." The book is divided into three parts and is narrated by multiple characters, providing different perspectives on the protagonists. The narrative spans over 20 years, following the poets' journey from Mexico City to Europe, Israel, and Africa, as they search for a mysterious poetess and navigate through the world of literature, sex, drugs, and the complexities of life.

The novel explores the complex dynamics of family and identity through the intertwined narratives of a brother and sister living in a marginalized community. As they navigate the challenges of their environment, the siblings grapple with issues of poverty, societal expectations, and personal aspirations. The story delves into their inner thoughts and struggles, revealing the profound impact of their circumstances on their sense of self and their relationship with each other. Through vivid and often fragmented prose, the narrative captures the raw and poignant realities of life on the fringes, offering a deep reflection on the human condition.

The novel is a reflective monologue by a dying Chilean priest and literary critic, Father Urrutia, who recounts his life and the political and cultural landscape of Chile during the Pinochet regime. As he navigates his memories, he grapples with his complicity and moral ambiguity, having mingled with influential literary figures and the elite while remaining largely passive in the face of the country's brutal dictatorship. The narrative explores themes of guilt, art, and the intersection of politics and literature, ultimately serving as a critique of intellectual complacency and the moral failures of those who choose silence over action.