This epic novel traces the lineage of two half-sisters from 18th century Ghana to present day America. One sister is sold into slavery and shipped to America, while the other is married off to a British slaver and remains in Africa. The book follows their descendants through the generations, exploring the lasting impact of slavery and colonialism on Black lives. The narrative showcases the struggles, resilience, and triumphs of each generation, providing a deep and personal view into the historical events and societal changes that shaped their lives.

Set in 19th century China, the novel centers around the lifelong friendship of Lily and Snow Flower. Despite their different social classes, the two communicate through a secret language known as "nu shu" written on a fan. The story explores the rigid societal norms of the time, particularly the practice of foot binding and arranged marriages. As they navigate through the hardships of their lives, their friendship is tested, leading to a devastating betrayal that impacts their relationship.