The book is a profound exploration of love, loyalty, and justice, centered on a young African American couple whose lives are shattered when the husband is wrongfully convicted of a crime he didn't commit. The narrative delves into the emotional turmoil that ensues, as the wife struggles with her obligations to her husband and her own desires for happiness. Through a series of letters exchanged between the couple during the husband's incarceration, and the perspectives of those entangled in their plight, the story examines the complexities of marriage, the impact of racial injustice on personal relationships, and the resilience required to overcome profound adversity.

"Fates and Furies" is a novel split into two parts, providing two perspectives on a single marriage. The first half of the book, "Fates," is told from the point of view of the husband, Lotto, a charismatic but failed actor turned successful playwright, who views his marriage as happy and his wife as supportive. The second half, "Furies," is told from the perspective of his wife, Mathilde, revealing her hidden past and the sacrifices and manipulations she has performed to maintain their life together. The novel explores themes of love, secrets, and the different narratives created within a relationship.

This novel follows the intertwined lives of three college graduates in the 1980s. The story focuses on the romantic entanglements of Madeleine Hanna, an English major who is writing her senior thesis on Jane Austen and George Eliot, and her relationships with two men: Leonard Bankhead, a charismatic but troubled biology student, and Mitchell Grammaticus, a religious studies student who is in love with Madeleine. The narrative explores the complexities of love, mental illness, faith, and the relevance of the traditional marriage plot in a modern world.