The novel explores the relationship between two remarkable women: Blanche Wittman, a patient at the Salpêtrière hospital in Paris who became a renowned medium, and Marie Curie, a physicist and chemist who conducted pioneering research on radioactivity. The book delves into their friendship, their scientific collaborations, and the profound impact they had on each other's lives. It also explores the broader themes of scientific discovery, the nature of genius, and the role of women in a male-dominated society.

"Harsh Cry of the Heron" is set in a mythical, feudal Japan-like setting and continues the tale of the Otori clan, focusing on Lord Takeo and his efforts to maintain peace across the Three Countries. Despite his commitment to a peaceful reign and the abolishment of violent practices like warfare and capital punishment, Takeo faces inevitable betrayal and threats from within his own ranks and from external enemies. As prophecies of doom surface, Takeo struggles with maintaining his ideals and the harsh realities of leadership, leading to a dramatic and poignant conclusion that tests the limits of loyalty, honor, and sacrifice.