This novel is a unique blend of six different stories, each set in a different time and place, spanning from the 19th century South Pacific to a post-apocalyptic future. Each tale is written in a different style, reflecting the time and setting it represents, and they are all connected through shared themes and recurring motifs. The stories are nested within each other, with each interrupted by the next, only to be concluded in the second half of the book. The novel explores themes of predacity, civilization, reincarnation and the eternal recurrence of the same behaviors throughout history.

A woman searches for her kidnapped daughter in a world ravaged by a catastrophic climate change event known as the Fifth Season. Simultaneously, the narrative follows a young girl with destructive powers and a man struggling to control his own similar abilities. The story explores themes of oppression, survival, and the destructive power of nature, all set in a dystopian world where the earth is constantly in flux, and society is strictly divided and controlled.

In a dystopian future where society has collapsed due to environmental and economic crises, a young woman named Lauren Olamina possesses a unique ability to feel the pain and pleasure of others. As she witnesses her community being torn apart by violence and religious fanaticism, Lauren embarks on a perilous journey to find a new safe haven and establish her own religion based on empathy and survival. Through her thought-provoking narrative, the book explores themes of resilience, spirituality, and the power of human connection in the face of adversity.

Set in a post-apocalyptic world, the novel follows the life of Snowman, who believes he may be the last human on earth, as he struggles to survive in a new, harsh environment. He is surrounded by genetically modified creatures, and his only companions are the Crakers, human-like beings created by his brilliant but disturbed friend Crake. Through Snowman's memories, the story of how the world came to be this way is revealed, involving a love triangle with the mysterious Oryx and the catastrophic consequences of Crake's scientific experiments.

Set in a future Thailand amidst a world ravaged by climate change and depleted resources, the story unfolds in a bustling city where biotech corporations vie for supremacy. The narrative centers around a genetically engineered "New Person," known as the Windup Girl, who is trapped in a life of servitude and exploitation. As the city teeters on the brink of political and environmental collapse, the fates of various characters—including a foreign energy investor, a disgraced geneticist, and a street-smart refugee—intertwine with that of the Windup Girl. Together, they navigate a treacherous landscape of corporate greed, oppressive government, and social upheaval, in a desperate search for survival and redemption in a world where every action has unforeseen consequences.

This novel is set in a post-apocalyptic Moscow, where the remnants of humanity have taken refuge in the underground metro system after a devastating nuclear war. The story follows Artyom, a young man who embarks on a perilous journey through the dark, mutant-infested tunnels of the metro to seek help against a new, mysterious threat that endangers the fragile existence of the metro's survivors. Along the way, he encounters various factions vying for power and control, confronts his deepest fears, and questions his beliefs and the nature of reality itself. The narrative weaves together themes of survival, hope, and the enduring human spirit in the face of overwhelming darkness.