"Station Eleven" is a post-apocalyptic novel that revolves around the lives of several characters before and after a devastating flu pandemic wipes out most of the world's population. The narrative jumps back and forth in time, exploring the interconnectedness of the characters' lives through their shared memories and experiences. The story also follows a traveling Shakespearean theatre company as they navigate the dangers of a collapsed civilization, emphasizing the importance of art and human connection in times of crisis.

In a dystopian future where people have lost the ability to dream, leading to widespread madness, Indigenous people in North America are hunted for their bone marrow, which holds the cure for the rest of the world's dreamlessness. The story follows a young Indigenous boy and his companions as they navigate this perilous landscape, struggling to survive against the government "recruiters" who seek to harvest their marrow. As they journey through the ravaged lands, they must rely on their wits, their cultural heritage, and each other to retain their humanity against a society that seeks to take everything from them, including their dreams.