"Station Eleven" is a post-apocalyptic novel that revolves around the lives of several characters before and after a devastating flu pandemic wipes out most of the world's population. The narrative jumps back and forth in time, exploring the interconnectedness of the characters' lives through their shared memories and experiences. The story also follows a traveling Shakespearean theatre company as they navigate the dangers of a collapsed civilization, emphasizing the importance of art and human connection in times of crisis.

The book explores the ecological history of the Great Lakes and the environmental challenges they face. It delves into the impact of invasive species, pollution, and overfishing, which have dramatically altered the aquatic ecosystems and threatened the lakes' health. Through a blend of scientific research and investigative journalism, the narrative highlights both the human-induced problems and the ongoing efforts for restoration and protection. The book serves as a critical examination of the balance between human activity and environmental preservation, emphasizing the importance of sustainable practices to safeguard these vital freshwater resources.