This book provides a comprehensive examination of the concept and practice of disease eradication from a historical perspective. It delves into the scientific, ethical, and political dimensions of the global efforts to eliminate diseases, focusing on case studies such as smallpox, malaria, and polio. The narrative critically assesses the successes and failures of these campaigns, highlighting the complexities and challenges involved in attempting to wipe out diseases. Through a detailed analysis, the book explores the implications of eradication efforts on public health policies and practices, questioning the feasibility and desirability of pursuing eradication as a goal in the face of evolving disease dynamics and global health landscapes.