Set during the French colonial war in Vietnam, this novel follows a British journalist and a young American idealist who become friends and find themselves in a love triangle with a Vietnamese woman. As the war escalates, the journalist becomes disillusioned with the American's naïve political views and the destructive impact of foreign intervention. The story is a critique of American involvement in Vietnam, exploring themes of love, friendship, and moral ambiguity.

Set in the 1950s on the fictional San Piedro Island in the northern Puget Sound region of the state of Washington, the plot revolves around the trial of Kabuo Miyamoto, a Japanese American accused of murdering Carl Heine, a respected fisherman in the close-knit community. The trial really serves as a means of exploring the inter-ethnic tensions of the post-WWII era, as flashbacks reveal the shared history of the island's residents including the forced internment of its Japanese population during the war. The novel also delves into the love affair between Ishmael Chambers, a local reporter, and Hatsue Miyamoto, Kabuo's wife.

Set in 1896 New York City, the novel follows a journalist and his friend, a psychologist (or "alienist"), as they work on an investigation into a series of gruesome murders of boy prostitutes. The team employs psychological profiling and early forensic methods to hunt down the serial killer. The book delves into the seedy underbelly of the city, exploring the grim realities of life at the time.