This novel tells the story of Dr. Wilbur Larch—saint and obstetrician, founder and director of the orphanage in the town of St. Cloud's, Maine, and a man of rare compassion and an addiction to ether. Dr. Larch loves all his orphans, especially Homer Wells, who is never adopted and becomes his invaluable apprentice. As Homer comes of age, he must leave the only home he's ever known to explore the world outside, a world filled with temptations and moral dilemmas, from the struggle over abortion to the question of what constitutes a family.

This novel follows the poignant journey of two teenagers, both cancer patients, who meet in a support group and fall in love. Their shared experiences and unique outlook on life and death bring them closer together, and they embark on a trip to Amsterdam to meet a reclusive author they both admire. Through their journey, they explore the harsh realities of living with a terminal illness while also experiencing the beautiful and tragic aspects of first love.

"Waiting" is a story set in China during the Cultural Revolution and its aftermath, revolving around the life of Lin Kong, a military doctor who is torn between his love for two women. He is stuck in an arranged marriage with his traditional wife in the countryside, while he falls in love with a modern, city nurse. The novel explores his 18-year struggle to divorce his wife and marry his lover, depicting the clash between traditional and modern Chinese culture, personal desires, and societal expectations.

"Saturday" is a novel that unfolds over a single day in London, following the life of a successful neurosurgeon. His day is disrupted by a violent encounter with a petty criminal, which leads to a series of tense situations that force him to confront his values, his family's safety, and his view of the world. The narrative explores themes of love, fear, and the randomness of life, all set against the backdrop of a post-9/11 world.

"Blaming" is a poignant story about a woman named Amy who, after the sudden death of her husband during a holiday, finds herself befriended by an American woman named Martha. Despite their differences, Martha provides Amy with comfort and support, but Amy finds it difficult to accept this kindness due to her reserved and private nature. The novel explores themes of grief, friendship, and the complexities of human relationships, as well as the guilt and blame individuals often place on themselves in times of hardship.

The novel follows the life of twin brothers born from a secret union between an Indian nun and a British surgeon in Ethiopia. Their mother dies during childbirth and their father disappears, leaving them to be raised by two doctors at the mission hospital where they were born. The story spans several decades and continents, and explores themes of love, betrayal, medicine, and the complexity of family ties. One of the brothers, a gifted surgeon, flees to America after a political revolution in Ethiopia, while the other remains and struggles with the challenges of practicing medicine in a developing country.