This novel follows the life of Antonia Shimerda, a Bohemian immigrant to the United States, through the eyes of her childhood friend, Jim Burden. The narrative explores their lives in the harsh environment of the American Midwest, their struggles with poverty, cultural adaptation, and personal growth. Antonia's resilience, strength, and love for life inspire Jim, who moves away for education and career but remains emotionally tied to the woman and the prairie life he left behind. The book is a compelling portrayal of pioneer life, human resilience, and the enduring power of friendship.

The novel follows the life of Claude Wheeler, a young Nebraska native who is dissatisfied with his prosperous farming life. When the United States enters World War I, he sees it as an opportunity to find purpose and meaning, and enlists in the army. The book explores his experiences and struggles in the war, his longing for home, and his ultimate sacrifice, providing a poignant commentary on the impact of war on the individual and society.