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“Polygenic risk” as a book category gathers works that explain, critique, and apply the science of how many common genetic variants, each with small effects, combine to influence traits and disease susceptibility. Titles in this genre span accessible introductions to complex-trait genetics, research monographs on genome-wide association studies and the construction and validation of polygenic risk scores, and clinical or public-health perspectives on using these scores for screening, prevention, and precision medicine. The shelf often includes case studies in cardiometabolic, psychiatric, and cancer risk; methodological texts in statistical genetics and machine learning; and examinations of portability across ancestries and other sources of bias. A strong strand addresses ethics, law, and society—privacy, consent, discrimination, equity, historical context, and the limits and controversies around prediction (including in reproduction or behavioral traits). Readers range from researchers, clinicians, and students to policymakers and informed general audiences seeking to understand what polygenic risk can—and cannot—tell us.

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