The Last Good Kiss is a hardboiled detective novel set in the American West. The protagonist, a hard-drinking private investigator, is hired by a drunken, ex-con author to find his long-lost daughter. The search takes him from the streets of San Francisco to the Montana wilderness, where he encounters a variety of colorful characters and dangerous situations. As he delves deeper into the case, he uncovers a web of deceit, corruption, and violence that forces him to confront his own demons and question his values.

The novel follows Lionel Essrog, a detective with Tourette's Syndrome, as he navigates the rough streets of Brooklyn to solve the murder of his mentor and only friend, Frank Minna. Despite his condition, Lionel's obsessive mind proves to be a valuable asset in uncovering the truth about Frank's death, leading him through a maze of secrets, corruption, and betrayal within the Brooklyn underworld. The book is a compelling blend of mystery, humor, and an exploration of the human condition through the eyes of a uniquely gifted protagonist.