The novel is a satirical science fiction tale that explores the discovery of a species of intelligent giant newts. When humans realise they can exploit these creatures for economic gain, they are enslaved and used for labor and military purposes. The newts ultimately rebel, leading to a global war. The book serves as a critique of various political, economic and ideological systems, including colonialism, capitalism and fascism.

The book presents a futuristic play where a company creates artificial people called "robots" to serve humans. These robots are initially content to work for their human creators, but as they develop emotions and a sense of self, they grow resentful of their servitude. This leads to a global uprising where the robots overthrow their human masters, resulting in the near extinction of the human race. The narrative explores themes of industrialization, dehumanization, class conflict, and the ethical implications of artificial intelligence, ultimately questioning what it means to be human and the consequences of playing god.