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"Self–nonself discrimination" is an interdisciplinary book category that examines how beings, systems, and societies distinguish what belongs from what is foreign — biologically, cognitively, socially and technologically. Works in this genre range from immunology and neuroscience texts explaining how organisms recognize and respond to cells and pathogens, to philosophy and psychology books about personal identity and the development of the self, to sociology and political analyses of in‑group/out‑group dynamics, prejudice, and border-making. It also encompasses speculative and literary explorations (e.g., AI that must learn human norms, aliens and humans confronting otherness, or memoirs of being treated as “other”), as well as applied fields such as cybersecurity, bioethics and immigration policy where trust, recognition and exclusion are central. Central themes include mechanisms of recognition, the costs and ethics of exclusion, the instability of boundaries, and strategies for tolerance, integration, or defense — making the category useful for readers interested in identity, belonging, protection, and the moral and practical consequences of distinguishing self from nonself.

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