The novel explores the spiritual isolation of misfits and outcasts in a small town of the U.S. South. Its protagonist is a deaf-mute who becomes the confidant for various troubled souls including a black physician, a bitter labor activist, a lonely young girl, and a struggling café owner. Each pours their heart out to him, but he remains unable to respond, reflecting the deep human need for connection and understanding.

"The Prince of Tides" is a gripping narrative about a troubled man who must confront his traumatic past in order to help his twin sister, a poet who has attempted suicide. The protagonist, in the process of aiding his sister's psychiatrist, is forced to delve into their shared history of growing up in a dysfunctional family in South Carolina. The story is a deep exploration of family dynamics, mental health, and the enduring impact of childhood trauma, all set against the backdrop of the Southern United States.

"Everything That Rises Must Converge" is a collection of nine short stories that explore themes of racial tension, family dynamics, and morality in the mid-20th century American South. The stories delve into the psyche of various characters, most of whom are grappling with the changing social and racial landscape of the time. The narratives often reveal the characters' inherent prejudices and their struggle to reconcile their beliefs with the evolving world around them.

"Paris Trout" is a gripping narrative set in a small Georgia town in the 1950s. The story revolves around a local store owner, Paris Trout, who kills a young black girl and injures her mother over a debt dispute. His violent act sends shockwaves through the town and his refusal to accept guilt, along with his lawyer's struggle to defend him, exposes the deep-seated racial and social tensions in the community. The book explores themes of racism, violence, and the moral decay of a society that allows such acts to go unpunished.

The novel centers around the life of a woman named Kate Vaiden, who at the age of 11, loses her parents in a murder-suicide. Kate is then raised by her aunt and uncle in North Carolina. At the age of 17, she becomes pregnant and, after giving birth, abandons her son, choosing to live a life of solitude. The story is told by Kate at the age of 57, as she reflects on her life and the decisions she's made, while also contemplating the possibility of reuniting with her abandoned son.

This novel tells the story of the Timberlake family, focusing on two sisters, Stanley and Roy. Stanley is a selfish, manipulative woman who abandons her husband for her sister Roy's husband, causing a series of tragic events. Meanwhile, Roy, the more responsible and virtuous sister, must navigate the fallout of Stanley's actions. The book explores themes of family, morality, and the destructive power of selfishness, all set against the backdrop of the American South in the early 20th century.