The book follows the story of Precious Ramotswe, a woman in Botswana who opens the country's first and only female-run detective agency. She uses wisdom, intuition, and her understanding of human nature to solve various cases, from missing husbands to wayward daughters and con men. The story is not just about solving mysteries, but also provides a deep insight into the culture, landscape and people of Botswana.

The novel explores the life of a young boy growing up in a small town in Argentina during the 1930s and 1940s. It is a coming-of-age story that uses a unique narrative structure, incorporating a mix of dialogues, inner thoughts, and film scripts to depict the protagonist's life. The boy's obsession with Hollywood films and glamorous actresses, particularly Rita Hayworth, serves as an escape from his oppressive environment and shapes his understanding of the world. The book also delves into themes of sexuality, identity, and the impact of popular culture.