The novel is a detailed narrative of a vengeful sea captain's obsessive quest to hunt down a giant white sperm whale that bit off his leg. The captain's relentless pursuit, despite the warnings and concerns of his crew, leads them on a dangerous journey across the seas. The story is a complex exploration of good and evil, obsession, and the nature of reality, filled with rich descriptions of whaling and the sea.

The novel is a poignant exploration of a young African-American man's journey through life, where he grapples with issues of race, identity, and individuality in mid-20th-century America. The protagonist, who remains unnamed throughout the story, considers himself socially invisible due to his race. The narrative follows his experiences from the South to the North, from being a student to a worker, and his involvement in the Brotherhood, a political organization. The book is a profound critique of societal norms and racial prejudice, highlighting the protagonist's struggle to assert his identity in a world that refuses to see him.

The novel follows the story of a young woman who wins a guest editorship at a magazine in New York City and, after a series of personal and professional disappointments, suffers a mental breakdown and returns to her family, where she continues to struggle with depression and suicidal thoughts. The protagonist's experiences in psychiatric institutions and her attempts to reclaim her life are depicted with brutal honesty, making it a poignant exploration of mental illness and the societal pressures faced by women in the mid-20th century.

Set in a psychiatric hospital in Oregon, the novel is narrated by a half-Native American patient known as Chief Bromden, who pretends to be deaf and mute. The story follows the arrival of a new patient, a boisterous, rebellious man who challenges the oppressive and dehumanizing system of the hospital, particularly the tyrannical Nurse Ratched. The book explores themes of individuality, rebellion, and the misuse of power, ultimately leading to a tragic conclusion.

"Affliction" is a powerful and haunting novel about a man named Wade Whitehouse, a small-town cop in New Hampshire, who descends into a spiral of violence and despair triggered by the fear of his own impotence. The narrative delves deep into Wade's past and present life, his struggles with alcoholism, his failed marriage and difficult relationship with his daughter, and his abusive father, all leading to a tragic and shocking climax. The book is a profound exploration of the struggle for self and identity in a harsh and unforgiving environment.

"October Light" is a story set in Vermont, revolving around an elderly brother and sister, James and Sally, who have lived together for decades but have a strained relationship due to their differing views. When James locks Sally in her room after an argument, she finds a novel within a novel, which becomes her only escape. The book explores themes of aging, isolation, and the clash of old and new values, all the while providing a commentary on the changing American society of the 1970s.

"Meteor in the Madhouse" is a posthumously published collection of interconnected novellas that delve into the complexities of African American life and identity. The narrative weaves through the experiences of various characters, primarily focusing on the protagonist's reflections on his life, his relationships with others, and his quest for understanding amidst the chaos of the world around him. The book explores themes of memory, history, and the interplay of reality and fiction, all set against the backdrop of the civil rights movement and the rich cultural tapestry of African American heritage. Through lyrical prose and a non-linear structure, the work challenges readers to contemplate the nature of storytelling and the power of the human spirit to endure and make sense of life's tumultuous journey.