The novel is set in the Algerian city of Oran during the 1940s, where a deadly plague sweeps through, causing the city to be quarantined. The story is told through the eyes of a doctor who witnesses the horror and suffering caused by the disease. The narrative explores themes of human resilience, solidarity, and the struggle against the absurdities of life. It also examines how individuals and society respond to death and disease, creating a profound meditation on the nature of existence and human endurance.

"La Grande Maison" is a novel that delves into the struggles and hardships of life in Algeria during the early 20th century, particularly focusing on the impact of colonialism. The story is told through the eyes of a young boy named Omar, who grows up in a large, impoverished family in a small Algerian village. As Omar navigates his childhood and adolescence, he becomes increasingly aware of the social and economic disparities that define his world, grappling with his aspirations for education and a better life against the backdrop of political upheaval and the fight for independence from French colonial rule. The novel poignantly captures the complex interplay of personal and political conflicts, portraying a community caught between tradition and change.