Set in the small town of Holt, Colorado, the novel delves into the lives of the aging McPheron brothers as they grapple with the loneliness and challenges of rural life after their surrogate daughter leaves for college. Simultaneously, the story follows a struggling young mother as she battles to keep her family together amidst poverty and social services intervention. The narrative weaves together the experiences of these characters and others in the community, painting a poignant and realistic portrait of small-town existence, with its interwoven relationships and the enduring human capacity for resilience and connection in the face of hardship.

The 8212th greatest book of all time