Cancer As A Metabolic Disease by Thomas N. Seyfried

On the Origin, Management, and Prevention of Cancer

The book argues that cancer is primarily a metabolic disease rooted in dysfunctional mitochondria and abnormal cellular energy production, rather than a disorder driven chiefly by gene mutations; as a result, cancer cells rely heavily on fermentative metabolism (glycolysis and glutaminolysis) to fuel growth. It reviews evidence from experimental and clinical studies supporting this view and outlines therapeutic implications focused on metabolic management—such as dietary modification (ketogenic diets, calorie restriction), targeting glucose and glutamine metabolism, and other strategies to restore normal energy metabolism or selectively starve tumor cells.

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