"A Hazard of New Fortunes" centers around Basil March, who relocates with his family from Boston to New York City to start a new literary magazine. The novel explores themes of social change, class conflict, and the pursuit of ethical living in a rapidly modernizing America. As the characters navigate the complexities of urban life and their personal ambitions, they encounter a diverse cast of characters that represent the varied social spectrum of New York City. The story delves into issues of wealth disparity, labor unrest, and the challenges of integrating different cultural and social backgrounds, reflecting the broader societal shifts of the late 19th century.

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