This novel is a dual narrative that explores the interconnected stories of a 15th-century Italian Renaissance artist named Francesco del Cossa and a modern-day teenager named George. The book is divided into two parts, one set in the past and one in the present, and the order in which they are read can change the reader's interpretation of the story. The novel delves into themes of art, gender, sexuality, and the fluidity of identity, while also examining the ways in which we perceive and understand the world around us.

"Tree of Smoke" is a war novel that explores the chaos, violence, and moral ambiguity of the Vietnam War. The story follows a diverse cast of characters, including a CIA operative, a young soldier, and a pair of missionaries, all of whom are trying to navigate the uncertainties and horrors of the war. The novel delves into themes of faith, fate, and the human capacity for both good and evil, offering a gritty and complex portrait of a turbulent period in history.