The novel is a sweeping historical narrative set in ancient Egypt, following the life of a physician named Sinuhe from his humble beginnings to his rise through Egyptian society. As a witness to the political machinations and cultural shifts of his time, Sinuhe encounters love, betrayal, and the complexities of human nature against the backdrop of significant historical events, including the reign of Pharaoh Akhenaten and the religious revolution he instigated. Through his travels and experiences, Sinuhe reflects on the nature of fate, power, and the eternal search for meaning in a changing world.