The novel explores the final hours of the Roman poet Virgil, who, while on his deathbed, contemplates the value and impact of his life's work, particularly his unfinished epic, the Aeneid. The narrative is a complex, stream-of-consciousness meditation on art, life, and death, with Virgil wrestling with his desire to burn his epic and the emperor's command to preserve it. The book delves into themes of the meaning of human existence, the role of art in society, and the clash between the individual's inner world and the external world.

"The Sheltering Sky" is a novel about an American couple, Port and Kit Moresby, who travel to the North African desert accompanied by their friend Tunner. The journey, initially an attempt to cure their marital woes, quickly descends into a harrowing journey of self-discovery and exploration of the human condition. As they move further into the desert, the harsh environment and their isolation from the outside world push them to their psychological limits, leading to devastating consequences.

Set in Chicago during World War II, the novel follows the life of a young man waiting to be drafted into the army. As he waits, he grapples with his feelings of isolation, frustration, and anxiety, which are exacerbated by his joblessness and the uncertainty of his future. His diary entries reveal his philosophical reflections on life, his struggles in his relationships, and his increasing mental instability as he feels more and more trapped by his circumstances.